TY - JOUR
T1 - A bioinformatic prediction of antigen presentation from SARS-CoV-2 spike protein revealed a theoretical correlation of HLA-DRB1*01 with COVID-19 fatality in Mexican population
T2 - An ecological approach
AU - Romero-López, José Pablo
AU - Carnalla-Cortés, Martha
AU - Pacheco-Olvera, Diana L.
AU - Ocampo-Godínez, Juan Moisés
AU - Oliva-Ramírez, Jacqueline
AU - Moreno-Manjón, Julia
AU - Bernal-Alferes, Brian
AU - López-Olmedo, Nancy
AU - García-Latorre, Ethel
AU - Domínguez-López, María Lilia
AU - Reyes-Sandoval, Arturo
AU - Jiménez-Zamudio, Luis
N1 - Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2021/4
Y1 - 2021/4
N2 - SARS-CoV-2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide. Human leukocyte antigen (HLA)-based epitope prediction and its association with disease outcomes provide an important base for treatment design. A bioinformatic prediction of T cell epitopes and their restricted HLA Class I and II alleles was performed to obtain immunogenic epitopes and HLA alleles from the spike protein of the severe acute respiratory syndrome coronavirus 2 virus. Also, a correlation with the predicted fatality rate of hospitalized patients in 28 states of Mexico was done. Here, we describe a set of 10 highly immunogenic epitopes, together with different HLA alleles that can efficiently present these epitopes to T cells. Most of these epitopes are located within the S1 subunit of the spike protein, suggesting that this area is highly immunogenic. A statistical negative correlation was found between the frequency of HLA-DRB1*01 and the fatality rate in hospitalized patients in Mexico.
AB - SARS-CoV-2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide. Human leukocyte antigen (HLA)-based epitope prediction and its association with disease outcomes provide an important base for treatment design. A bioinformatic prediction of T cell epitopes and their restricted HLA Class I and II alleles was performed to obtain immunogenic epitopes and HLA alleles from the spike protein of the severe acute respiratory syndrome coronavirus 2 virus. Also, a correlation with the predicted fatality rate of hospitalized patients in 28 states of Mexico was done. Here, we describe a set of 10 highly immunogenic epitopes, together with different HLA alleles that can efficiently present these epitopes to T cells. Most of these epitopes are located within the S1 subunit of the spike protein, suggesting that this area is highly immunogenic. A statistical negative correlation was found between the frequency of HLA-DRB1*01 and the fatality rate in hospitalized patients in Mexico.
UR - http://www.scopus.com/inward/record.url?scp=85092306823&partnerID=8YFLogxK
U2 - 10.1002/jmv.26561
DO - 10.1002/jmv.26561
M3 - Artículo
C2 - 32986250
AN - SCOPUS:85092306823
SN - 0146-6615
VL - 93
SP - 2029
EP - 2038
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 4
ER -