In the present study the acetylcholinesterase (AChE) inhibition and acute toxicity of two succinic acid derivatives were compared with tacrine. Administration of a single dose of each of two succinic acid derivatives produced a time and dose-dependent inhibition of brain AChE activity. Although the magnitude of the cholinergic effects observed with the two succinic acid derivatives was similar to that seen with tacrine and other AChE inhibitors, the toxicity study showed that the new inhibitors have less adverse side effects.
|Original language||American English|
|Number of pages||340|
|State||Published - 15 Dec 2005|
|Event||Chemico-Biological Interactions - |
Duration: 15 Dec 2005 → …
|Period||15/12/05 → …|
Raya, J. E., Correa-Basurto, J., Alcántara, J. I. V., & Trujillo-Ferrara, J. G. (2005). (17) Effects of succinic acid derivatives on ex vivo acetylcholinesterase activity. 379-380. Paper presented at Chemico-Biological Interactions, . https://doi.org/10.1016/j.cbi.2005.10.062