TY - JOUR
T1 - α-Glucosidase and α-amylase inhibition potentials of ten wild Mexican species of Verbenaceae
AU - Ávila-Reyes, José A.
AU - Almaraz-Abarca, Norma
AU - Alvarado, Eli A.Delgado
AU - Torres-Ricario, Rene
AU - Naranjo-Jiménez, Néstor
AU - Gutierrez-Velazquez, Marcela V.
AU - González-Valdez, Laura S.
AU - Uribe-Soto, José N.
AU - Vasavilbazo-Saucedo, Andres
N1 - Publisher Copyright:
© 2019 The authors.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: To evaluate the inhibitory activity of 10 wild Verbenaceae species from Mexico against α-glucosidase and α-amylase.Methods: Ethanol leaf extracts of 10 Verbenaceae species from Mexico were prepared. The inhibitoryactivity of the extracts against α-glucosidase and α-amylase was evaluated using enzymatic protocols.At least four serial diluted concentrations of each extract was used to calculate the half-maximalinhibitory concentration (IC50).Results: The 10 evaluated Verbenaceae species showed high α-glucosidase inhibition activity, but alow inhibitory effect on α-amylase. Aloysia gratissima (IC50 = 0.122 mg/mL), Verbena carolina (IC50 =0.112 mg/mL), Bouchea prismatica (IC50 = 0.122 mg/mL), Verbena menthiflora (IC50 = 0.071mg/mL)and Priva mexicana (IC50 = 0.032 mg/mL) exhibited the strongest inhibitory activities against α-glucosidase.Conclusion: All the Verbenaceae species studied possess α-glucosidase inhibitory effect, with P.mexicana being the one with the strongest activity. These findings demonstrate the highs potential ofthese species as a source of natural antihyperglycemic agents for type 2 diabetes therapy.
AB - Purpose: To evaluate the inhibitory activity of 10 wild Verbenaceae species from Mexico against α-glucosidase and α-amylase.Methods: Ethanol leaf extracts of 10 Verbenaceae species from Mexico were prepared. The inhibitoryactivity of the extracts against α-glucosidase and α-amylase was evaluated using enzymatic protocols.At least four serial diluted concentrations of each extract was used to calculate the half-maximalinhibitory concentration (IC50).Results: The 10 evaluated Verbenaceae species showed high α-glucosidase inhibition activity, but alow inhibitory effect on α-amylase. Aloysia gratissima (IC50 = 0.122 mg/mL), Verbena carolina (IC50 =0.112 mg/mL), Bouchea prismatica (IC50 = 0.122 mg/mL), Verbena menthiflora (IC50 = 0.071mg/mL)and Priva mexicana (IC50 = 0.032 mg/mL) exhibited the strongest inhibitory activities against α-glucosidase.Conclusion: All the Verbenaceae species studied possess α-glucosidase inhibitory effect, with P.mexicana being the one with the strongest activity. These findings demonstrate the highs potential ofthese species as a source of natural antihyperglycemic agents for type 2 diabetes therapy.
KW - Aloysia gratissima
KW - Bouchea prismatica
KW - Diabetes
KW - Hyperglycemic
KW - Priva mexicana
KW - α-Amylase Verbenaceae
KW - α-Glucosidase
UR - http://www.scopus.com/inward/record.url?scp=85061538693&partnerID=8YFLogxK
U2 - 10.4314/tjpr.v18i1.5
DO - 10.4314/tjpr.v18i1.5
M3 - Artículo
AN - SCOPUS:85061538693
SN - 1596-5996
VL - 18
SP - 31
EP - 36
JO - Tropical Journal of Pharmaceutical Research
JF - Tropical Journal of Pharmaceutical Research
IS - 1
ER -